Our Reagents Portfolio
Our reagent portfolio offers flexibility of vial sizes and provides superb onboard stability across our Haemostasis analyzers.
In 2010, Sysmex Corporation acquired HYPHEN BioMed enabling us to provide a comprehensive line of reagents to complement our existing Siemens haemostasis reagents portfolio. HYPHEN BioMed is a scientific company with experience in the field of thrombosis, haemostasis and auto-immunity, producing a full line of diagnostic and research reagents, distributed worldwide.
Please contact your respective Sysmex representative for other Hyphen diagnostic and research products
Reagents Products
PT
Dade Innovin
Dade Innovin Reagent is prepared from purified recombinant human tissue factor produced in E. coli, combined with synthetic phospholipids, calcium, buffers, and stabilisers. It is highly sensitive to extrinsic factor deficiencies and oral anticoagulant-treated patient plasma samples. The sensitivity of Dade Innovin Reagent is very similar to that of the WHO human brain reference thromboplastin. It is insensitive to therapeutic levels of heparin, which, in combination with high sensitivity to coagulation factors, makes Dade Innovin Reagent ideal for monitoring oral anticoagulant therapy and differentiating abnormal plasmas, even in the mildly pathological range.
Thromborel S
Thromborel S Reagent is prepared from human placental tissue factor combined with calcium chloride and stabilisers. The reagent contains minimal residual clotting factors, such as prothrombin or factors VII or X, for clear definition of factor deficiencies and steep factor assay curves. Because of its high sensitivity to these coagulation factors, the reagent is suitable for monitoring oral anticoagulant therapy. Thromborel S Reagent exhibits good correlation with the WHO international reference thromboplastin preparation. With the Thromborel S Reagent and the appropriate deficient plasma, it is possible to determine activity of coagulation factors II, V, VII, and X. The reagent differentiates abnormal plasmas, even in the mildly pathological range.
APTT
Dade Actin
Dade Actin Reagent has moderate sensitivity to factor deficiencies (VIII, IX, XI, and XII) in the intrinsic system. It is the ideal choice for institutions requiring a moderate screening APTT reagent for routine testing. Dade Actin Activated Cephaloplastin Reagent has low heparin sensitivity, allowing the monitoring of heparin therapy even with high heparin dosage. It has moderate sensitivity to lupus anticoagulants.
Dade Actin FS
Dade Actin FS Reagent is a highly sensitive reagent for the detection of factor deficiencies (VIII, IX, XI and XII) of the intrinsic system. With moderate sensitivity to lupus anticoagulants and high sensitivity to heparin, it fulfills all requirements of routine coagulation testing.
Dade Actin FSL
Dade Actin FSL Reagent exhibits increased sensitivity to lupus anticoagulants and moderate heparin sensitivity. The reagent shows good factor sensitivity to detect clinically significant deficiencies of the intrinsic system.
Pathromtin SL
Pathromtin SL Reagent exhibits high sensitivity to lupus anticoagulants, factor deficiencies, and heparin.
Fibrinogen
Dade Thrombin
Dade Thrombin Reagent is an effective reagent for use in the determination (Clauss method) of fibrinogen in the detection of hereditary or acquired hypo- and hyperfibrinogenemia, dysfibrinogenemia, and afibrinogenemia. The reagent offers long stability after reconstitution.
Dade Fibrinogen Determination Reagents
The Dade Fibrinogen Determination Reagent consists of Dade Thrombin Reagent, Fibrinogen Standard, and Dade Owren’s Veronal Buffer for use in the determination of fibrinogen (Clauss method) in the detection of hereditary or acquired hypo- and hyperfibrinogenemia, dysfibrinogenemia, and afibrinogenemia. The reagent offers long stability after reconstitution.
Multifibren U Reagent
Multifibren U Reagent is a bovine thrombin reagent used in the modified Clauss determination of fibrinogen for the detection of hereditary or acquired hypo-and hyperfibrinogenemia and dysfibrinogenemia. The reagent is insensitive to heparin up to 2.0 U/mL and has a wide measuring range of 0.80–12.00 g/L.
Thrombin Time
Test Thrombin
Test Thrombin Reagent is intended for the determination of thrombin time in citrated human plasma. The reagent is suitable for monitoring of fibrinolytic therapy, screening for disorders of fibrin formation, in suspected cases of severe fibrinogen deficiency states, and for differentiation between heparin-induced prolongation of thrombin time and disorders of fibrinogen formation. Thrombin time is found to be prolonged not only due to disorders in fibrin polymerisation, but also due to the presence of heparin. Differentiation can be achieved using Batroxobin Reagent.
Thromboclotin
Thromboclotin Reagent is intended for the determination of thrombin time in citrated human plasma. The reagent is suitable for monitoring of fibrinolytic therapy, screening for disorders of fibrin formation, in suspected cases of severe fibrinogen deficiency states, and for differentiation between heparin-induced prolongation of the thrombin time and disorders of fibrinogen formation. Thrombin time is found to be prolonged not only due to disorders in fibrin polymerization, but also due to the presence of heparin. Differentiation can be achieved using Batroxobin Reagent.
Batroxobin Time
Batroxobin
Batroxobin Reagent is a snake venom-based reagent intended for the determination of the batroxobin time. It is ideal for monitoring fibrinolytic therapy by determination of fibrinogen/fibrin degradation products, diagnosis of afibrinogenemia and dysfibrinogenemia, and elucidation of prolonged thrombin times in cases of suspected presence of heparin.
Deficient Factor
Factor II Deficient Plasma
Coagulation Factor II Deficient Plasma is a human plasma-based reagent for the detection of hereditary or acquired deficiencies of factor II (prothrombin). It is manufactured by immunoabsorption and contains a residual factor concentration of 1% prothrombin activity and normal levels of fibrinogen and other extrinsic clotting factors. Coagulation Factor II Deficient Plasma was designed to be used in combination with Dade Innovin or Thromborel S Reagents.
Factor V Deficient Plasma
Coagulation Factor V Deficient Plasma is a human plasma-based reagent for the detection of hereditary or acquired deficiencies of factor V. It is manufactured by immunoabsorption and contains a residual factor concentration of 1% factor V activity and normal levels of fibrinogen and other extrinsic clotting factors. Coagulation Factor V Deficient Plasma was designed to be used in combination with Dade Innovin or Thromborel S Reagents.
Factor VII Deficient Plasma
Coagulation Factor VII Deficient Plasma is a human plasma-based reagent for the detection of hereditary or acquired deficiencies of factor VII. It is manufactured by immunoabsorption and contains a residual factor concentration of 1% factor VII activity and normal levels of fibrinogen and other extrinsic clotting factors. Coagulation Factor VII Deficient Plasma was designed to be used in combination with Dade Innovin or Thromborel S Reagents.
Factor VIII Deficient Plasma
Coagulation Factor VIII Deficient Plasma is a human plasma-based reagent for the detection of hereditary or acquired deficiencies of factor VIII (haemophilia A). With a residual factor activity of less than 1%, the reagent is ideal for the monitoring of substitution therapy. Coagulation Factor VIII Deficient Plasma was designed to be used in combination with Dade Actin, Dade Actin FS, Dade Actin FSL, or Pathromtin SL Reagents.
Factor IX Deficient Plasma
Coagulation Factor IX Deficient Plasma is a human plasma-based reagent for the detection of hereditary or acquired deficiencies of factor IX (haemophilia B). With a residual factor activity of less than 1%, the reagent is ideal for the monitoring of substitution therapy. Coagulation Factor IX Deficient Plasma was designed to be used in combination with Dade Actin, Dade Actin FS, Dade Actin FSL, or Pathromtin SL Reagents.
Factor X Deficient Plasma
Coagulation Factor X Deficient Plasma is a human plasma-based reagent for the detection of hereditary or acquired deficiencies of factor X. It is manufactured by immunoabsorption and contains a residual factor concentration of less than 1% factor X activity and normal levels of fibrinogen and other extrinsic clotting factors. Coagulation Factor X Deficient Plasma was designed to be used in combination with Dade Innovin or Thromborel S Reagents.
Factor XI Deficient Plasma
Coagulation Factor XI Deficient Plasma is a human plasma-based reagent for the detection of hereditary or acquired deficiencies of factor XI. The reagent has a residual factor concentration of less than 1% factor XI activity and was designed to be used in combination with Dade Actin, Dade Actin FS, Dade Actin FSL, or Pathromtin SL Reagents.
Factor XII Deficient Plasma
Coagulation Factor XII Deficient Plasma is a human plasma-based reagent for the detection of hereditary or acquired deficiencies of factor XII. The reagent has a residual factor concentration of less than 1% factor XII activity and was designed to be used in combination with Dade Actin, Dade Actin FS, Dade Actin FSL, or Pathromtin SL Reagents.
Berichrom Factor VIII Chromogenic
The Factor VIII Chromogenic Assay is recommended for factor FVIII determination in therapeutic factor FVIII preparations and the detection of hereditary or acquired factor VIII deficiencies. The chromogenic method is insensitive to heparin at levels of less than 10 IU/mL.
Berichrom Factor XIII Chromogenic
The Berichrom Factor XIII Kit is a chromogenic, quantitative assay for the detection of hereditary or acquired factor XIII deficiencies. The chromogenic activity reagent is also used for the monitoring of patients undergoing factor XIII substitution therapy.
Platelet Function
Revohem ADP
160 µmol/L of ADP. Investigation of platelet aggregation induced by ADP.
Revohem Epinephrine
0.8 mmol/L of Epinephrine. Investigation of platelet aggregation induced by Epinephrine.
Revohem Arachidonic Acid
12 mmol/L of Arachidonic Acid. Investigation of platelet aggregation induced by Arachidonic Acid.
Revohem Ristocetin
12 mg/mL of Ristocetin. Measurement of the von Willebrand Factor Ristocetin cofactor by platelet aggregation.
Revohem Collagen
0.8 mg/mL of Collagen. Investigation of platelet aggregation induced by Collagen.
Lupus Anticoagulant
LA1 screening
LA 1 Screening Reagent contains dilute Russell’s viper venom and low phospholipids for use in the simplified DRVVT as a screening test for lupus anticoagulants. The LA 1 Screening Reagent was designed to be used in conjunction with the LA 2 Confirmation Reagent.
LA2 confirmation
LA 2 Confirmation Reagent is a simplified dilute Russell’s viper venom test rich in phospholipids, making it ideal for the confirmation of lupus anticoagulants. The LA 2 Confirmation Reagent was designed to be used in conjunction with the LA 1 Screening Reagent.
D-Dimer
Innovance D-Dimer
The INNOVANCE D-Dimer Kit is a rapid, highly precise, and sensitive test system for the determination of D-dimer. It offers high diagnostic sensitivity of >98% for exclusion of VTE (venous thromboembolism). With its extended assay range, D-dimer levels can be used for the diagnosis and monitoring of patients with disseminated intravascular coagulopathy (DIC), as well as for the monitoring of anticoagulation treatment and pregnancy-related coagulopathies (e.g., preeclampsia and HELLP syndrome).
Berichrom α2-Antiplasmin
Berichrom α2-Antiplasmin Kit is used for the determination of α2-Antiplasmin and the detection of hereditary or acquired α2-Antiplasmin deficiencies. The chromogenic activity assay is also applicable for the monitoring of fibrinolytic therapy.
Berichrom Plasminogen
Berichrom Plasminogen Kit, a chromogenic activity test system, is used for the determination of plasminogen and the detection of hereditary or acquired plasminogen deficiencies.
Berichrom PAI Kit
The Berichrom PAI Kit is a chromogenic test system for the determination of plasminogen activator inhibitor (PAI) levels as an indicator of a thrombophilic state and hypofibrinolysis. The reagent is not influenced by α2-antiplasmin or FDP.
FDP
Latex Test BL-2 P-FDP
Latex Test BL-2 P-FDP is a reagent in which a latex agglutination reaction is employed as the principle to optically perform quantitative measurement of FDP in plasma
Protein C Pathway
Protein C
Protein C Reagent is a coagulometric reagent used for the quantitative determination of protein C activity. The reagent is suitable for the detection of hereditary or acquired protein C deficiencies.
Berichrom Protein C
The Berichrom Protein C Kit, a chromogenic activity assay, is used for the detection of hereditary or acquired protein C deficiency types. The assay is also used for the monitoring of substitution therapy with protein C concentrates in congenital protein C deficiency. The Berichrom Protein C Kit is less susceptible to interfering substances than a clotting assay.
ProC Global
ProC Global Kit is a coagulometric screening reagent for the protein C pathway. It provides a determination of the anticoagulatory capacity of the protein C system. The heparin-insensitive reagent is useful in screening individuals affected by thrombophilia. ProC Global Kit is sensitive to deficiencies of factor V Leiden and proteins C and S, certain lupus anticoagulants, and high factor VIII levels. When use in combination with FV deficient plasma, it screen for the detection of factor V Leiden.
Protein S Ac
Protein S Ac Reagent, a coagulometric activity reagent, is used for the detection of hereditary or acquired protein S deficiencies.
INNOVANCE Free PS Ag
The INNOVANCE Free PS Ag Kit is an easy-to-use, highly specific, and stable test for the quantitative detection of free protein S in human plasma. It is based on monoclonal antibodies and employs polystyrene particles covalently coated with two monoclonal antibodies (mAb A and mAb B) that have high specificity for free protein S and do not bind to protein S/C4b-binding protein complexes; the high specificity also shows no major interferences, including interferences commonly incurred from rheumatoid factors and heterophilic antibodies. The ready-to-use liquid reagent provides excellent stability performance as well as precision.
Antithrombin
Berichrom Antithrombin III (A)
The Berichrom Antithrombin III (A) Kit is a chromogenic activity assay for the detection of hereditary or acquired antithrombin deficiency and monitoring of patients undergoing substitution therapy. The heparin co-factor-independent lyophilized reagent uses bovine thrombin and exhibits no interference with anti-FXa anticoagulants (e.g., rivaroxaban).
INNOVANCE Antithrombin
The INNOVANCE Antithrombin Kit is an automated chromogenic assay for the quantitative determination of functional antithrombin. The human factor Xa-based reagent has minimal interference with heparin cofactor II and thrombin inhibitors such as hirudin. The ready-to-use liquid reagents provide excellent precision and reliability.
Von Willebrand factor
vWF Ag
vWF Ag Kit contains is a quantitative, automated immunoassay used to determine the differentiation of quantitative versus qualitative von Willebrand factor deficiencies. It is sensitive to type 1 and 3 VWF deficiencies and offers a wide measuring range of 2–600%.
INNOVANCE VWF Ac
The INNOVANCE VWF Ac Kit is a sensitive, reliable, and convenient test system for direct determination of VWF activity. It employs an advanced new technology that allows the assay to mimic the way in which VWF binds to glycoprotein Ib (GPIb), the major VWF receptor protein on platelets. Latex particles are coated with an antibody against GPIb, to which recombinant GPIb is added. The addition of patient plasma induces a VWF-dependent agglutination, which is detected turbidimetrically. Because the recombinant receptor protein includes two gain-of-function mutations, the assay does not require ristocetin.
BC von Willebrand Reagent
BC von Willebrand Reagent provides a simple, rapid, and automated procedure for the determination of the ristocetin cofactor activity of von Willebrand factor. The reagent, which provides a rapid measurement time, is sensitive to types 1, 2, and 3 of von Willebrand disease (except VWD 2N) and is the recommended screening method for von Willebrand disease.
LMWH
Biophen Heparin LRT
Biophen Heparin LRT is a liquid chromogenic assay developed for measuring homogeneously unfractionated heparin (UFH) and LMWH, using the same calibration curve. This method is also useful for the determination of anti-Xa activity of Orgaran (sodium danaparoid) and Arixtra (Fondaparinux), indirect inhibitors whose activity is mediated by plasma AT, and for the determination of direct anti-Xa inhibitors (Rivaroxaban, Apixaban and Edoxaban), using specific calibrations.
UFH
Biophen Heparin LRT
Biophen Heparin LRT is a liquid chromogenic assay developed for measuring homogeneously unfractionated heparin (UFH) and LMWH, using the same calibration curve. This method is also useful for the determination of anti-Xa activity of Orgaran (sodium danaparoid) and Arixtra (Fondaparinux), indirect inhibitors whose activity is mediated by plasma AT, and for the determination of direct anti-Xa inhibitors (Rivaroxaban, Apixaban and Edoxaban), using specific calibrations.
Orgaran
Biophen Heparin LRT
Biophen Heparin LRT is a liquid chromogenic assay developed for measuring homogeneously unfractionated heparin (UFH) and LMWH, using the same calibration curve. This method is also useful for the determination of anti-Xa activity of Orgaran (sodium danaparoid) and Arixtra (Fondaparinux), indirect inhibitors whose activity is mediated by plasma AT, and for the determination of direct anti-Xa inhibitors (Rivaroxaban, Apixaban and Edoxaban), using specific calibrations.
Arixtra
Biophen Heparin LRT
Biophen Heparin LRT is a liquid chromogenic assay developed for measuring homogeneously unfractionated heparin (UFH) and LMWH, using the same calibration curve. This method is also useful for the determination of anti-Xa activity of Orgaran (sodium danaparoid) and Arixtra (Fondaparinux), indirect inhibitors whose activity is mediated by plasma AT, and for the determination of direct anti-Xa inhibitors (Rivaroxaban, Apixaban and Edoxaban), using specific calibrations.
Rivaroxaban
Biophen Heparin LRT
Biophen Heparin LRT is a liquid chromogenic assay developed for measuring homogeneously unfractionated heparin (UFH) and LMWH, using the same calibration curve. This method is also useful for the determination of anti-Xa activity of Orgaran (sodium danaparoid) and Arixtra (Fondaparinux), indirect inhibitors whose activity is mediated by plasma AT, and for the determination of direct anti-Xa inhibitors (Rivaroxaban, Apixaban and Edoxaban), using specific calibrations.
Biophen DiXal
The Biophen DiXaI kit is a two stages chromogenic method specific to direct Factor Xa inhibitors (DiXaIs), such as Rivaroxaban, Apixaban or Edoxaban and is insensitive to heparins (UFH and LMWH).
Apixaban
Biophen Heparin LRT
Biophen Heparin LRT is a liquid chromogenic assay developed for measuring homogeneously unfractionated heparin (UFH) and LMWH, using the same calibration curve. This method is also useful for the determination of anti-Xa activity of Orgaran (sodium danaparoid) and Arixtra (Fondaparinux), indirect inhibitors whose activity is mediated by plasma AT, and for the determination of direct anti-Xa inhibitors (Rivaroxaban, Apixaban and Edoxaban), using specific calibrations.
Biophen DiXal
The Biophen DiXaI kit is a two stages chromogenic method specific to direct Factor Xa inhibitors (DiXaIs), such as Rivaroxaban, Apixaban or Edoxaban and is insensitive to heparins (UFH and LMWH).
Edoxaban
Biophen Heparin LRT
Biophen Heparin LRT is a liquid chromogenic assay developed for measuring homogeneously unfractionated heparin (UFH) and LMWH, using the same calibration curve. This method is also useful for the determination of anti-Xa activity of Orgaran (sodium danaparoid) and Arixtra (Fondaparinux), indirect inhibitors whose activity is mediated by plasma AT, and for the determination of direct anti-Xa inhibitors (Rivaroxaban, Apixaban and Edoxaban), using specific calibrations.
Biophen DiXal
The Biophen DiXaI kit is a two stages chromogenic method specific to direct Factor Xa inhibitors (DiXaIs), such as Rivaroxaban, Apixaban or Edoxaban and is insensitive to heparins (UFH and LMWH).
Dabigatran
HEMOCLOT Thrombin Inhibitors
HEMOCLOT Thrombin Inhibitors is a clotting assay for quantitative measurement of Dabigatran and other Direct Thrombin Inhibitors (DTIs) such as the Argatroban or Hirudin.
Biophen DTI
Biophen DTI kit is an anti-IIa chromogenic method for quantitative determination of Dabigatran and other Direct Thrombin Inhibitors (FIIa) like Hirudin
Argatroban
HEMOCLOT Thrombin Inhibitors
HEMOCLOT Thrombin Inhibitors is a clotting assay for quantitative measurement of Dabigatran and other Direct Thrombin Inhibitors (DTIs) such as the Argatroban or Hirudin.
Hirudin
HEMOCLOT Thrombin Inhibitors
HEMOCLOT Thrombin Inhibitors is a clotting assay for quantitative measurement of Dabigatran and other Direct Thrombin Inhibitors (DTIs) such as the Argatroban or Hirudin.
Complement
Berichrom C1-Inhibitor
The Berichrom C1-Inhibitor Kit, a human C1 esterase-based assay, determines the presence of C1 inhibitors in patient samples. The reagent offers a fast-turnaround time to result of <10 minutes and detects hereditary or acquired deficiencies of the C1 inhibitor (e.g., in angioneurotic edema). This chromogenic activity reagent is used for the diagnosis of diminished C1-inhibitor synthesis, increased consumption and for monitoring substitution therapy and androgen therapy.