Advancement in Haematological Diseases

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1. Recent advance in the diagnosis and treatment of paroxysmal nocturnal hemoglobinuria (PNH)

Discussion on the recent progress in the pathogenesis, diagnosis and treatment of Paroxysmal nocturnal hemoglobinuria (PNH).

Professor Yuzuru KANAKURA, M.D., Ph.D. The Department of Hematology and Oncology, Osaka University Graduate School of Medicine

2. Understanding of genetic alterations in myeloproliferative neoplasms

Introduction of a research findings of JAK2V617F, CALR, and MPL mutations in patients suspected of Philadelphia-negative myeloproliferative neoplasm (MPN), as well as discussion on surrounding issues.

Professor Norio KOMATSU, M.D., Ph.D. Department of Hematology, Juntendo University School of Medicine

3. On the genetic basis of myelodysplastic syndromes

Summary of major advances of recent years in the ﬁeld of MDS research, focusing on the results of the studies by Prof. Ogawa’s team.

Professor Seishi OGAWA, M.D., Ph.D.,Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University

4. Antithrombin resistance: a new mechanism of inherited thrombophilia

Introduction of a study investigating a possible causative gene defect in the large Japanese family with inherited thrombophilia, as well as the discovery of a novel missense mutation in the prothombin gene (p.ARG596Leu) resulting in a variant prothrombin.

Professor Tetsuhito KOJIMA, M.D., Ph, D.Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine

5. Progress and vision in the treatment of hemophilia

An overview of the recent progress and vision in the treatment of hemophilia including clinical trials on therapeutic drugs and gene therapy.

Professor Midori SHIMA, M.D., Ph, D.Department of Pediatrics, Nara Medical University

1. Recent advance in the diagnosis and treatment of paroxysmal nocturnal hemoglobinuria (PNH)

Advancement in Haematological Diseases

1. Recent advance in the diagnosis and treatment of paroxysmal nocturnal hemoglobinuria (PNH)

1. Recent advance in the diagnosis and treatment of paroxysmal nocturnal hemoglobinuria (PNH)

2. Understanding of genetic alterations in myeloproliferative neoplasms

2. Understanding of genetic alterations in myeloproliferative neoplasms

3. On the genetic basis of myelodysplastic syndromes

3. On the genetic basis of myelodysplastic syndromes

4. Antithrombin resistance: a new mechanism of inherited thrombophilia

4. Antithrombin resistance: a new mechanism of inherited thrombophilia

5. Progress and vision in the treatment of hemophilia

5. Progress and vision in the treatment of hemophilia

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